Moderate Hemophilia A: Managing the Mid-Level Clotting Disorder

Moderate Hemophilia A is a clotting disorder in dogs, characterized by a moderate deficiency in Factor VIII, a crucial clotting factor. Dogs with this condition experience prolonged bleeding and bruising tendencies, falling between the severity of mild and severe Hemophilia A. In this in-depth article, we delve into the nuances of Moderate Hemophilia A in dogs, understanding its clinical impact, diagnostic approaches, and effective management strategies to ensure optimal canine health.

Understanding Hemophilia A

Hemophilia A is a hereditary bleeding disorder primarily affecting male dogs, caused by a deficiency or dysfunction of Factor VIII.

Grading Hemophilia A Severity

  1. Mild Hemophilia A: Characterized by a residual Factor VIII activity of 6-40% of normal levels.
  2. Moderate Hemophilia A: Residual Factor VIII activity ranges from 1-5% of normal levels.
  3. Severe Hemophilia A: Residual Factor VIII activity is less than 1% of normal levels.

Clinical Impact of Moderate Hemophilia A

  1. Prolonged Bleeding: Dogs with Moderate Hemophilia A experience prolonged bleeding after injuries or surgeries.
  2. Bruising Tendencies: Spontaneous bruising and hematomas are common due to impaired clotting.

Diagnosing Moderate Hemophilia A

  1. Clinical Evaluation: History of prolonged bleeding, bruising, and clinical signs are crucial in suspecting Hemophilia A.
  2. Coagulation Tests: Specific coagulation tests, including Factor VIII activity assays, confirm the diagnosis and determine its severity.

Management and Treatment

  1. Preventive Measures: Avoiding activities with potential injury risks can reduce bleeding episodes.
  2. Desmopressin Therapy: Desmopressin administration can temporarily increase Factor VIII levels in dogs with Moderate Hemophilia A.
  3. Factor VIII Replacement: In severe bleeding episodes or before surgeries, Factor VIII replacement therapy may be necessary.

Monitoring and Prognosis

  1. Regular Veterinary Checkups: Routine monitoring ensures early detection of bleeding episodes and timely interventions.
  2. Quality of Life: With appropriate management, dogs with Moderate Hemophilia A can lead a good quality of life.

Genetic Counseling and Breeding Considerations

  1. Inherited Trait: Moderate Hemophilia A is a hereditary condition, and breeding dogs should undergo genetic testing.
  2. Preventing Transmission: Selective breeding based on genetic test results helps prevent the transmission of Hemophilia A to future generations.

Supporting Canine Health

  1. Education and Awareness: Raising awareness about Hemophilia A can lead to early detection and timely interventions.
  2. Informed Decisions: Understanding the severity of Hemophilia A aids in making informed decisions for optimal canine care.


Moderate Hemophilia A is a significant clotting disorder in dogs, requiring careful monitoring and appropriate management. Understanding the clinical impact and diagnostic approaches is essential for early detection and timely interventions. By providing tailored care and adopting informed breeding practices, we can ensure the well-being of our beloved canine companions affected by Moderate Hemophilia A, promoting a happy and healthy life for these special members of our families.